Pan-cancer analysis reveals the potential of hyaluronate synthase as therapeutic targets in human tumors

Hyaluronic acid (HA) is a crucial component of the extracellular matrix, and its level accumulation related to progression various malignant tumors. In this study, pan-cancer analysis three enzymes called hyaluronan synthases (HAS1, HAS2, HAS3) that produce HA was performed. The study comprehensively describes characteristics HAS1, HAS3 in cancers using public databases tools, identify potential biological pathways involved at molecular, protein, cellular, clinical sample levels. showed dysregulation genes often occurs cancer, contributing cancer progression, metastasis, prognosis. Overexpression HAS2 promotes secretion GBM enhances cell proliferation migration. common specific functions HAS certain diseases have important research implications for treatment prognosis